COX‐2 as a potential blood based biomarker and a possible therapeutic target in Alzheimer’s Disease
Sakshi Kumari, Sharmistha Dey · 2025
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Description
Sakshi Kumari and Sharmistha Dey published a study in 2025 on a protein linked to swelling in the brain in Alzheimer's disease. The protein, called COX-2, rises when amyloid triggers immune cells and harms nerve cells. The pair asked whether blood levels of the protein could flag the disease early, and whether blocking it could help.
They measured the protein and its gene activity in blood from patients and healthy people. Levels were higher in patients with the disease or mild impairment, though they fell as illness wore on. A small peptide they designed bound the protein and protected nerve-like cells in the lab. Both a test and a treatment idea rest on these results.
Catalog record
| CREATOR | Sakshi Kumari, Sharmistha Dey |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |