Microglial Activation Captured by Diffusion‐Weighted MRI and sTREM2 in Alzheimer’s Disease
Gohar Zavradyan, Ilana J Bennett, Sneha Padmanaban, Seerat Kang, Sindhuja Kuncharapu · 2025
Read Microglial Activation Captured by Diffusion‐Weighted MRI and sTREM2 in Alzheimer’s Disease by Gohar Zavradyan, Ilana J Bennett, Sneha Padmanaban, Seerat Kang, Sindhuja Kuncharapu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716847.txt.
Description
Gohar Zavradyan and co-authors test in 2025 whether a diffusion based brain scan can catch microglial activation in Alzheimer disease. Microglia are the brain's immune cells; when roused they swell and their branches shrink, changes that should alter how water moves in tissue. Animal work hinted that this kind of scan can feel that shift, and a spinal fluid marker offers a check.
Using data from a large Alzheimer imaging program, the team compared patients with healthy and mildly impaired older adults. Water diffusion ran higher in two deep brain areas in the patient group, and the fluid marker of microglial activity was also higher. In patients, diffusion in one of those areas, the caudate, tracked the fluid marker closely, while the other area did not. The split result supports the scan as a partial window on brain inflammation.
Catalog record
| CREATOR | Gohar Zavradyan, Ilana J Bennett, Sneha Padmanaban, Seerat Kang, Sindhuja Kuncharapu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |