Synaptic proteins in pre‐symptomatic Alzheimer's disease: genes implicate synaptic biomarkers to the early detection of cognitive decline
Jiarui Ao, Anne Labonté, Cynthia Picard, Ann Brinkmalm, Kaj Blennow, John CS Breitner, Henrik Zetterberg, Sylvia Villeneuve, Judes Poirier, PREVENT‐AD Research Group · 2025
Read Synaptic proteins in pre‐symptomatic Alzheimer's disease: genes implicate synaptic biomarkers to the early detection of cognitive decline by Jiarui Ao, Anne Labonté, Cynthia Picard, Ann Brinkmalm, Kaj Blennow, John CS Breitner, Henrik Zetterberg, Sylvia Villeneuve, Judes Poirier, PREVENT‐AD Research Group (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716837.txt.
Description
Jiarui Ao and a team of co-authors published a study in 2025 on proteins at the synapses of people at risk for Alzheimer's disease. Synapses are the junctions where nerve cells pass signals, and they fail early in the disease. The team asked whether genes point to certain synaptic proteins as early warning signs of decline.
They measured four such proteins in spinal fluid from symptom-free older adults with a family history of the disease. They also tracked thinking scores over time and studied brain tissue from a second group. Some protein levels tracked closely with later decline, making them candidates for very early testing. The genes involved may also suggest new paths for treatment research.
Catalog record
| CREATOR | Jiarui Ao, Anne Labonté, Cynthia Picard, Ann Brinkmalm, Kaj Blennow, John CS Breitner, Henrik Zetterberg, Sylvia Villeneuve, Judes Poirier, PREVENT‐AD Research Group |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |