Sex‐ and lineage‐specific effects of cannabidiol in mouse models of Alzheimer’s Disease – a PET scan and behavioral study
Lidia Emmanuela Wiazowski Spelta, Chiara Maria Righini, Jean Marques Brizola, Daniele de Paula de Paula Faria · 2025
Read Sex‐ and lineage‐specific effects of cannabidiol in mouse models of Alzheimer’s Disease – a PET scan and behavioral study by Lidia Emmanuela Wiazowski Spelta, Chiara Maria Righini, Jean Marques Brizola, Daniele de Paula de Paula Faria (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716832.txt.
Description
Lidia Emmanuela Wiazowski Spelta, Chiara Maria Righini, and their co-authors tested cannabidiol in two mouse models of Alzheimer's disease, split by sex and strain. Their 2025 study notes that the cannabis compound shows protective and calming effects in early work, but no single model captures the disease's many faces. Comparing models and sexes could sharpen future trials.
Two strains of model mice, male and female, received the compound or a plain vehicle for thirty days at seven months of age. At eight months, behavior tests gauged exploration and memory through object recognition. Brain scans with two tracers measured degeneration and inflammation. The design asks whether benefits depend on the model, the sex, or both, a question human therapy planning often skips.
Catalog record
| CREATOR | Lidia Emmanuela Wiazowski Spelta, Chiara Maria Righini, Jean Marques Brizola, Daniele de Paula de Paula Faria |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |