A shared behavioral framework for assessing preserved cognitive function in aging in rodent models
Audrey E Branch, Joseph McQuail, Catherine C. Kaczorowski, Thomas C Foster, John F. Disterhoft, Matthew J. Huentelman, Peter R. Rapp, Carol A Barnes · 2025
Read A shared behavioral framework for assessing preserved cognitive function in aging in rodent models by Audrey E Branch, Joseph McQuail, Catherine C. Kaczorowski, Thomas C Foster, John F. Disterhoft, Matthew J. Huentelman, Peter R. Rapp, Carol A Barnes (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716830.txt.
Description
Audrey Branch and co-authors describe a shared framework for testing thinking in aging rodents across laboratories, in work published in 2025. Animal studies can reveal what protects the aging brain, but behavior tests are rarely run the same way in each lab. That gap blocks data sharing and joint work.
The group built a standard reporting frame and a central database, centered on a water maze test of place learning. Four labs have added data so far, which allows comparisons across strain, sex, and age. Plans include tissue banks and more behavior measures for the same animals. The authors aim to grow a resource that supports collaboration on cognitive aging and resilience.
Catalog record
| CREATOR | Audrey E Branch, Joseph McQuail, Catherine C. Kaczorowski, Thomas C Foster, John F. Disterhoft, Matthew J. Huentelman, Peter R. Rapp, Carol A Barnes |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |