Prognostic value of neuroinflammation [11C]PK11195 PET on longitudinal cognitive decline and survival up to 15 years after PET in Alzheimer's disease
Roos M Rikken, Maqsood Yaqub, Emma M Coomans, Anne E van der Vlies, Frederik Barkhof, Albert D Windhorst, Yolande AL Pijnenburg, Wiesje M van der Flier, Ronald Boellaard, Everard GB Vijverberg, Elsmarieke van de Giessen · 2025
Read Prognostic value of neuroinflammation [11C]PK11195 PET on longitudinal cognitive decline and survival up to 15 years after PET in Alzheimer's disease by Roos M Rikken, Maqsood Yaqub, Emma M Coomans, Anne E van der Vlies, Frederik Barkhof, Albert D Windhorst, Yolande AL Pijnenburg, Wiesje M van der Flier, Ronald Boellaard, Everard GB Vijverberg, Elsmarieke van de Giessen (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716822.txt.
Description
Roos Rikken and co-authors ask whether brain inflammation, seen on a PET scan, foretells decline in Alzheimer's disease. Inflammation is a known player in the disease, but its power to predict the course was unclear. Their 2025 study follows 29 amyloid-positive people, some with mild loss and some with dementia. Scans used a tracer that tags an inflammation protein. Memory scores were then tracked for up to eleven years.
Survival was tracked for up to fifteen years past the scan. Inflammation reads came from two cortex zones and were scaled against young healthy controls. Mixed models weighed the scan against age, sex, and schooling. The long follow-up is rare for such scans. The team aims to learn if one scan can sort fast from slow courses.
Catalog record
| CREATOR | Roos M Rikken, Maqsood Yaqub, Emma M Coomans, Anne E van der Vlies, Frederik Barkhof, Albert D Windhorst, Yolande AL Pijnenburg, Wiesje M van der Flier, Ronald Boellaard, Everard GB Vijverberg, Elsmarieke van de Giessen |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |