Multi‐Parametric MRI assessment of biomarkers in a non‐human primate model exhibiting sporadic cerebral amyloid angiopathy
Suleiman Khan, Sean Murray, Jakub Szabo, Muhammad T Soliman, Hannah Goldman, Michael Llanos, Olivia Cho, Emily Schissler, Charles Kingsley, Jody Swain, Stanton B Gray, William D Hopkins, Jelle Veraart, Thomas Wisniewski, Youssef Zaim‐Wadghiri, Henrieta Scholtzova · 2025
Read Multi‐Parametric MRI assessment of biomarkers in a non‐human primate model exhibiting sporadic cerebral amyloid angiopathy by Suleiman Khan, Sean Murray, Jakub Szabo, Muhammad T Soliman, Hannah Goldman, Michael Llanos, Olivia Cho, Emily Schissler, Charles Kingsley, Jody Swain, Stanton B Gray, William D Hopkins, Jelle Veraart, Thomas Wisniewski, Youssef Zaim‐Wadghiri, Henrieta Scholtzova (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716803.txt.
Description
Suleiman Khan and co-authors scanned aged squirrel monkeys with several MRI methods in a 2025 study of a brain vessel disease. The disease coats small brain vessels with amyloid, a hallmark also seen in Alzheimer disease, and it raises the risk of side effects from new Alzheimer drugs. Squirrel monkeys develop this vessel disease on their own as they age, making them a rare natural model.
The team combined three scan types across age groups: one maps iron-sensitive signals, one shows water and swelling, and one probes tissue structure through water movement. Brain tissue checks after scanning let them match images to real pathology. Earlier work showed the iron map catches age-linked change and spots drug-like side effects. The study pushes the monkey model toward use in drug safety testing.
Catalog record
| CREATOR | Suleiman Khan, Sean Murray, Jakub Szabo, Muhammad T Soliman, Hannah Goldman, Michael Llanos, Olivia Cho, Emily Schissler, Charles Kingsley, Jody Swain, Stanton B Gray, William D Hopkins, Jelle Veraart, Thomas Wisniewski, Youssef Zaim‐Wadghiri, Henrieta Scholtzova |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |