Plasma p‐tau231 in the presenilin 1 E280A autosomal dominant Alzheimer’s disease kindred: a cross‐sectional and longitudinal cohort study
Vincent Malotaux, Nicholas J Ashton, Annika Öhrfelt, Yinghua Chen, Yi Su, Gloria Garcia, Claudia F Guzman, Andres Villegas‐Lanau, Margarita M Giraldo‐Chica, David Fernando Aguillon, Victoria Tirado, Ana Y Baena, Claudia Muñoz, Natalia Acosta‐Baena, Jeremy J Pruzin, Valentina Ghisays, Silvia Ríos‐Rom · 2025
Read Plasma p‐tau231 in the presenilin 1 E280A autosomal dominant Alzheimer’s disease kindred: a cross‐sectional and longitudinal cohort study by Vincent Malotaux, Nicholas J Ashton, Annika Öhrfelt, Yinghua Chen, Yi Su, Gloria Garcia, Claudia F Guzman, Andres Villegas‐Lanau, Margarita M Giraldo‐Chica, David Fernando Aguillon, Victoria Tirado, Ana Y Baena, Claudia Muñoz, Natalia Acosta‐Baena, Jeremy J Pruzin, Valentina Ghisays, Silvia Ríos‐Rom (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716783.txt.
Description
Vincent Malotaux and a large team of co-authors published a study in 2025 on a blood marker in a Colombian family with inherited Alzheimer's disease. Many members carry a gene mutation that brings the disease in mid-life, making the family a rare window on its earliest stages. The team tracked a tau-related blood marker in carriers and relatives without the mutation.
More than thirteen hundred people took part, and a smaller group was followed for about five years. Blood samples were measured with an ultra-sensitive test built in Sweden. Carriers and non-carriers were compared across ages to estimate when the marker first rises. Such timing helps trials choose when to start treatment in people destined for the disease.
Catalog record
| CREATOR | Vincent Malotaux, Nicholas J Ashton, Annika Öhrfelt, Yinghua Chen, Yi Su, Gloria Garcia, Claudia F Guzman, Andres Villegas‐Lanau, Margarita M Giraldo‐Chica, David Fernando Aguillon, Victoria Tirado, Ana Y Baena, Claudia Muñoz, Natalia Acosta‐Baena, Jeremy J Pruzin, Valentina Ghisays, Silvia Ríos‐Rom |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |