Performance of an AI‐based prediction model versus stratified thresholds using plasma biomarkers for biological staging of AD
Marina Scop Madeiros, Pamela CL Ferreira, Guilherme Bauer‐Negrini, Guilherme Povala, Bruna Bellaver, Cristiano Schaffer Aguzzoli, Carolina Soares, Hussein Zalzale, Markley Oliveira, Matheus Scarpatto Rodrigues, Sarah Abbas, Livia Amaral, Cynthia Felix, Pampa Saha, Emma Patrice Ruppert, Devin J Fine, · 2025
Read Performance of an AI‐based prediction model versus stratified thresholds using plasma biomarkers for biological staging of AD by Marina Scop Madeiros, Pamela CL Ferreira, Guilherme Bauer‐Negrini, Guilherme Povala, Bruna Bellaver, Cristiano Schaffer Aguzzoli, Carolina Soares, Hussein Zalzale, Markley Oliveira, Matheus Scarpatto Rodrigues, Sarah Abbas, Livia Amaral, Cynthia Felix, Pampa Saha, Emma Patrice Ruppert, Devin J Fine, (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716776.txt.
Description
Marina Scop Madeiros and a large team of co-authors published a study in 2025 on staging Alzheimer's disease with blood tests. The work asks whether two plasma markers, called GFAP and p-tau217, can place a person in the right stage of the disease. It compares a simple method based on fixed cutoff values with a model built with machine learning.
The team studied 362 people from the TRIAD cohort and sorted them into five stages using brain scans as the standard. The learning model, an ensemble of boosted trees, proved the most accurate of the methods tried. Readers get a clear test of whether cheap blood tests can stand in for costly scans.
Catalog record
| CREATOR | Marina Scop Madeiros, Pamela CL Ferreira, Guilherme Bauer‐Negrini, Guilherme Povala, Bruna Bellaver, Cristiano Schaffer Aguzzoli, Carolina Soares, Hussein Zalzale, Markley Oliveira, Matheus Scarpatto Rodrigues, Sarah Abbas, Livia Amaral, Cynthia Felix, Pampa Saha, Emma Patrice Ruppert, Devin J Fine, |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |