The Effect of Sex‐Differences on the Relationship Between White Matter Hyperintensity, Cerebrovascular Reactivity, and Fluid Biomarkers
Ahmed A Bahrani, Yang Jiang, David K Powell, Yuriko Katsumata, Azadeh Nahvi, Tiffany Lee, Brian T Gold, Larry B Goldstein, Donna M Wilcock, Gregory A Jicha, Peter T Nelson, Christopher M Norris · 2025
Read The Effect of Sex‐Differences on the Relationship Between White Matter Hyperintensity, Cerebrovascular Reactivity, and Fluid Biomarkers by Ahmed A Bahrani, Yang Jiang, David K Powell, Yuriko Katsumata, Azadeh Nahvi, Tiffany Lee, Brian T Gold, Larry B Goldstein, Donna M Wilcock, Gregory A Jicha, Peter T Nelson, Christopher M Norris (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716765.txt.
Description
Ahmed Bahrani and co-authors explored whether sex changes how blood markers relate to brain vessel health in older adults, in a study published in 2025. White matter bright spots on scans mark vessel damage tied to Alzheimer's and vascular dementia. The team studied twenty-seven participants, average age near seventy-seven, from two research cohorts. They correlated inflammation and vessel-growth markers in blood with scan measures of damage and vessel reactivity.
Women showed links between occipital white matter damage and three inflammation-related markers, while men showed only one link, to an amyloid marker. Vessel reactivity correlations also split by sex and brain region. Two markers stood out overall after adjustment, one tied to damage in several lobes. The authors stress the sample is small and preliminary. They argue sex-specific pathways deserve a place in dementia biomarker research.
Catalog record
| CREATOR | Ahmed A Bahrani, Yang Jiang, David K Powell, Yuriko Katsumata, Azadeh Nahvi, Tiffany Lee, Brian T Gold, Larry B Goldstein, Donna M Wilcock, Gregory A Jicha, Peter T Nelson, Christopher M Norris |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |