Identification of stage‐specific blood biomarkers for early diagnosis of Alzheimer’s disease through RNA sequencing analysis
Akiko Yamakawa, Mutsumi Suganuma, Risa Mitsumori, Shumpei Niida, Kouichi Ozaki, Daichi Shigemizu · 2025
Read Identification of stage‐specific blood biomarkers for early diagnosis of Alzheimer’s disease through RNA sequencing analysis by Akiko Yamakawa, Mutsumi Suganuma, Risa Mitsumori, Shumpei Niida, Kouichi Ozaki, Daichi Shigemizu (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716762.txt.
Description
Akiko Yamakawa and five co-authors published a study in 2025 on stage-specific blood markers for Alzheimer's disease, read from gene activity. Genes switch on and off as the disease moves from normal thinking to mild impairment to dementia. A marker that fits one stage may fail at another, so the team mapped both steps separately.
They sequenced RNA from more than twelve hundred blood samples across the three stages. Each step had its own set of changed genes, over eight hundred in the first step and over eleven hundred in the second. Small gene sets predicted each step fairly well. Early steps leaned on protein-making machinery, while later steps leaned on immune genes.
Catalog record
| CREATOR | Akiko Yamakawa, Mutsumi Suganuma, Risa Mitsumori, Shumpei Niida, Kouichi Ozaki, Daichi Shigemizu |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |