Plasma biomarkers of neurodegeneration in the brain (UCH‐L1 and NfL) become exponentially higher with age from early childhood, and treatment of Alzheimer’s disease participants with granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) lowers age‐associated levels of plasma UCH‐L1 by six decade
Stefan H Sillau, Christina M Coughlan, Md Mahiuddin Ahmed, Kavita V Nair, Paula Araya, Matthew D Galbraith, Brianne M Bettcher, Joaquin M Espinosa, Heidi J Chial, Neill Epperson, Timothy D Boyd, Huntington Potter · 2025
Read Plasma biomarkers of neurodegeneration in the brain (UCH‐L1 and NfL) become exponentially higher with age from early childhood, and treatment of Alzheimer’s disease participants with granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) lowers age‐associated levels of plasma UCH‐L1 by six decade by Stefan H Sillau, Christina M Coughlan, Md Mahiuddin Ahmed, Kavita V Nair, Paula Araya, Matthew D Galbraith, Brianne M Bettcher, Joaquin M Espinosa, Heidi J Chial, Neill Epperson, Timothy D Boyd, Huntington Potter (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716753.txt.
Description
Stefan H Sillau and eleven co-authors published a study in 2025 on blood markers of nerve cell death across the human lifespan. Two markers rise as the brain ages, but no test can yet track nerve loss in a living person. The team also tested whether a drug that boosts immune cells can push one marker back down in Alzheimer's patients.
They measured the markers in blood from early childhood onward and found levels climb steeply with age. In patients given the drug for three weeks, one marker fell to levels seen in people six decades younger. The work links a simple blood test to aging and treatment response. More work is needed to show whether lowering the marker also protects thinking.
Catalog record
| CREATOR | Stefan H Sillau, Christina M Coughlan, Md Mahiuddin Ahmed, Kavita V Nair, Paula Araya, Matthew D Galbraith, Brianne M Bettcher, Joaquin M Espinosa, Heidi J Chial, Neill Epperson, Timothy D Boyd, Huntington Potter |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |