APOE‐ε4 is associated with poor sleep and structural differences of the hypothalamus in the PREVENT‐Dementia and ALFA cohort studies
Axel AS Laurell, Elijah Mak, Benjamin R Underwood, Yves Dauvilliers, Craig W Ritchie, Ivan Koychev, Brian A Lawlor, Lorina Naci, Paresh Malhotra, Oriol Grau‐Rivera, Juan Domingo Gispert, John T O'Brien · 2025
Read APOE‐ε4 is associated with poor sleep and structural differences of the hypothalamus in the PREVENT‐Dementia and ALFA cohort studies by Axel AS Laurell, Elijah Mak, Benjamin R Underwood, Yves Dauvilliers, Craig W Ritchie, Ivan Koychev, Brian A Lawlor, Lorina Naci, Paresh Malhotra, Oriol Grau‐Rivera, Juan Domingo Gispert, John T O'Brien (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716748.txt.
Description
A gene variant that raises Alzheimer risk may also disturb sleep and change a small brain area that controls sleep. Axel Laurell and co-authors tested that link in this 2025 study across two large groups of healthy middle-aged adults. Together the groups held more than two thousand people, sorted by their gene risk.
Sleep was rated with a standard survey covering quality, timing, and how well people felt they slept. Brain scans were used to measure five parts of the sleep-control area. Data from many scanners were aligned so results could be pooled fairly. Poor sleep is now seen as a dementia risk factor in its own right. Showing a gene-driven path to poor sleep could point to earlier, targeted sleep care for people at high risk.
Catalog record
| CREATOR | Axel AS Laurell, Elijah Mak, Benjamin R Underwood, Yves Dauvilliers, Craig W Ritchie, Ivan Koychev, Brian A Lawlor, Lorina Naci, Paresh Malhotra, Oriol Grau‐Rivera, Juan Domingo Gispert, John T O'Brien |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |