Simvastatin restores neurovascular coupling and cognition in APP mice
Maria Paula Faccin Huth, Miled Bourourou, Frédéric Lesage, Edith Hamel, Aline R Zimmer · 2025
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Description
Maria Paula Faccin Huth and four co-authors published a mouse study in 2025 on a cholesterol drug and Alzheimer's disease. In the disease, blood flow in the brain responds poorly when nerve cells become active, and this failure shows up early. The team tested whether simvastatin, a widely used drug, could restore that response.
They tracked blood flow signals and learning in mice bred to develop the disease, from three to eight months of age. The sick mice showed weak responses early, before memory problems appeared. After five months on the drug, both blood flow response and memory returned to normal levels. The result points to blood vessel health as a drug target early in the disease.
Catalog record
| CREATOR | Maria Paula Faccin Huth, Miled Bourourou, Frédéric Lesage, Edith Hamel, Aline R Zimmer |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |