The Modifying Effects of Sex, Race, and Social Relationships on the Association between White Matter Integrity and Dementia Risk: The Atherosclerosis Risk in Communities (ARIC) Neurocognitive Study
Surabhee Eswaran, Rebecca F Gottesman, David S Knopman, Silvia Koton, Anna M Kucharska‐Newton, Albert C Liu, Chelsea Liu, Pamela L Lutsey, Thomas H Mosley, Priya Palta, A Richey Sharrett, Kevin J Sullivan, Keenan A Walker, Renee Groechel · 2025
Read The Modifying Effects of Sex, Race, and Social Relationships on the Association between White Matter Integrity and Dementia Risk: The Atherosclerosis Risk in Communities (ARIC) Neurocognitive Study by Surabhee Eswaran, Rebecca F Gottesman, David S Knopman, Silvia Koton, Anna M Kucharska‐Newton, Albert C Liu, Chelsea Liu, Pamela L Lutsey, Thomas H Mosley, Priya Palta, A Richey Sharrett, Kevin J Sullivan, Keenan A Walker, Renee Groechel (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716735.txt.
Description
Damage to the brain's white matter raises dementia risk, yet many people with such damage never develop the disease. Surabhee Eswaran and co-authors asked whether strong social ties soften that risk, in a 2025 study from a long-running heart health cohort. They also checked whether the answer changes by sex and by race.
The study followed 1,679 adults who were free of dementia in mid-life. In the early 1990s, participants reported on their social relationships and were classed as strong or poor in ties. Brain scans two decades later measured white matter integrity, and cases of dementia were tracked through 2019. The team weighed how ties and scan measures each fed into risk, within race and sex subgroups. The work treats mid-life friendship and support as factors that may blunt the harm of brain change.
Catalog record
| CREATOR | Surabhee Eswaran, Rebecca F Gottesman, David S Knopman, Silvia Koton, Anna M Kucharska‐Newton, Albert C Liu, Chelsea Liu, Pamela L Lutsey, Thomas H Mosley, Priya Palta, A Richey Sharrett, Kevin J Sullivan, Keenan A Walker, Renee Groechel |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |