Regional Amyloid Load Predicts Tau and Atrophy Dynamics
Pavan Chaggar, Jacob W Vogel, Alexa Pichet Binette, Travis B Thompson, Olof Strandberg, Niklas Mattsson‐Carlgren, Linda Karlsson, Erik Stomrud, Saad Jbabdi, Stefano Magon, Gregory Klein, Oskar Hansson, Alain Goriely · 2025
Read Regional Amyloid Load Predicts Tau and Atrophy Dynamics by Pavan Chaggar, Jacob W Vogel, Alexa Pichet Binette, Travis B Thompson, Olof Strandberg, Niklas Mattsson‐Carlgren, Linda Karlsson, Erik Stomrud, Saad Jbabdi, Stefano Magon, Gregory Klein, Oskar Hansson, Alain Goriely (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716733.txt.
Description
Thirteen authors led by Pavan Chaggar model how amyloid load in each brain zone foretells tau growth and tissue loss there. Alzheimer disease spreads through the brain in a set order of stages. Their model treats tau as made and moved along brain links, fit to scan data over time. Cohorts came from two large studies and spanned the full span from no marks to both marks of the disease.
The base model replays the known stage order of tau spread with care. In a group with amyloid but no tau yet, tau spread ran fast while its making ran slow, a split from the full disease group. A grown model then ties zone amyloid to zone tau change and shrinkage in one frame. That tie may let doctors track each zone path for one patient.
Catalog record
| CREATOR | Pavan Chaggar, Jacob W Vogel, Alexa Pichet Binette, Travis B Thompson, Olof Strandberg, Niklas Mattsson‐Carlgren, Linda Karlsson, Erik Stomrud, Saad Jbabdi, Stefano Magon, Gregory Klein, Oskar Hansson, Alain Goriely |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |