Modifiable risk factors for age‐at‐onset of Alzheimer’s disease through genetic determinants
Yi‐Ju Li, Jong ok La, Qiao Fan, Eden R Martin · 2025
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Description
Yi-Ju Li, Jong ok La, Qiao Fan, and Eden Martin ask which changeable risk factors shift the age at which Alzheimer's disease begins. Their 2025 study notes that age and genes, the known drivers, cannot be changed. Lifestyle and health factors can, but their effect on onset age, rather than on risk itself, was little studied.
The team pooled genetic data from about 9,200 cases and 10,300 controls across twenty cohorts. They built genetic scores for thirty-eight exposures, covering illness, lifestyle, and social factors. Scores were tested against onset age, adjusting for sex and a key gene. Exposures passing a strict threshold were then checked for causal effect with a second method.
Catalog record
| CREATOR | Yi‐Ju Li, Jong ok La, Qiao Fan, Eden R Martin |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |