Auranofin Alleviates Cognitive Deficit Induced by Cladribine in Experimental Rats
Khadga Raj Aran · 2025
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Description
Khadga Raj Aran published a rat study in 2025 on whether an old gold-based drug can protect the brain. A cancer drug called cladribine can raise toxic amyloid and harm thinking in animals. The gold drug auranofin fights inflammation and cell damage, and it has shown protective effects in other work.
Rats received the cancer drug for twenty-eight days, with or without one of two doses of the gold drug. Treated rats kept better recognition and spatial memory than untreated ones. Their brain tissue showed less inflammation, less amyloid, and healthier signaling chemicals. The higher dose worked better. The results support testing this drug class further in models of Alzheimer's-like damage.
Catalog record
| CREATOR | Khadga Raj Aran |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |