Plasma and MRI biomarkers predict post‐mortem tau pathology
Mingzhao Hu, Christina M Moloney, Scott A Przybelski, Alicia Algeciras‐Schimnich, Angela J Fought, Darren M Rothberg, Aivi T Nguyen, Ross R Reichard, Dennis W Dickson, David S Knopman, Clifford R Jack, Ronald C Petersen, Michelle M Mielke, Jonathan Graff‐Radford, Melissa E Murray, Prashanthi Vemuri · 2025
Read Plasma and MRI biomarkers predict post‐mortem tau pathology by Mingzhao Hu, Christina M Moloney, Scott A Przybelski, Alicia Algeciras‐Schimnich, Angela J Fought, Darren M Rothberg, Aivi T Nguyen, Ross R Reichard, Dennis W Dickson, David S Knopman, Clifford R Jack, Ronald C Petersen, Michelle M Mielke, Jonathan Graff‐Radford, Melissa E Murray, Prashanthi Vemuri (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716689.txt.
Description
Blood tests and brain scans are used to spot Alzheimer's disease in life, but how well they foretell the tau tangles found in the brain after death is less clear. Hu and co-authors built prediction models for sixty-three people whose brains were examined at autopsy. Before death, each person had given blood samples and MRI scans, and the team related those measures to the tau staining found later in the hippocampus and parietal cortex.
Scan-based models clearly beat blood-based ones. Hippocampal volume alone predicted the hippocampal tau load best, explaining about half its variation, while parietal thickness did better than parietal volume for the cortex. Blood markers explained only a fifth to a quarter of the variation. The authors conclude that regional MRI tracks tau pathology well, and they urge tests of newer scan methods for sharper specificity.
Catalog record
| CREATOR | Mingzhao Hu, Christina M Moloney, Scott A Przybelski, Alicia Algeciras‐Schimnich, Angela J Fought, Darren M Rothberg, Aivi T Nguyen, Ross R Reichard, Dennis W Dickson, David S Knopman, Clifford R Jack, Ronald C Petersen, Michelle M Mielke, Jonathan Graff‐Radford, Melissa E Murray, Prashanthi Vemuri |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |