Proteomic Signature of The Cerebrospinal Fluid (CSF) in Preclinical and prodromal AD: A key role for adhesion proteins
Reem M Neal, zhiyi Yang, Ihab Hajjar · 2025
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Description
Reem Neal, Zhiyi Yang, and Ihab Hajjar hunt early Alzheimer's signals in 2025 in spinal fluid. Most protein studies focus on late disease, yet the silent preclinical stage may be the best window to intervene. The team measures 276 proteins tied to nerve injury, vessel function, and metabolism in 354 study participants.
Comparing people by a spinal fluid marker ratio that flags Alzheimer's risk, they find hub proteins linked to disease markers and clinical traits. Six key genes differ by risk status, and several are adhesion proteins that help cells stick and signal. The authors argue these early protein patterns could guide intervention before symptoms.
Catalog record
| CREATOR | Reem M Neal, zhiyi Yang, Ihab Hajjar |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |