causal effects of air pollution on dementia: a mendelian randomized study
YUNYUN GUO, Shireen Sindi, Rui Wang, Lefkos T Middleton, Miia Kivipelto · 2025
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Description
Guo and co-authors use genetics to test whether air pollution actually causes dementia, rather than merely traveling with it. Observational studies link dirty air to higher dementia rates, but they cannot fully separate pollution from poverty, lifestyle, and other risks. Mendelian randomization uses inherited gene variants as a natural experiment to get closer to cause and effect.
Drawing on large genetic databases, the team tested four pollutants against several dementia types. Coarser particles, PM10, and nitrogen dioxide showed causal links to Alzheimer's disease risk, while the finest particles and nitrogen oxides did not show convincing effects. The authors call for animal and long-term population studies to uncover how these pollutants harm the brain.
Catalog record
| CREATOR | YUNYUN GUO, Shireen Sindi, Rui Wang, Lefkos T Middleton, Miia Kivipelto |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |