ATP1A3 as a target for isolating neuron‐specific extracellular vesicles from human brain and biofluids
Zhengrong Zhang, Yang You, Nadia Sultana, Maria Ericsson, Yuka A Martens, Min Sun, Takahisa Kanekiyo, Seiko Ikezu, Tsuneya Ikezu, Scott A Shaffer · 2025
Read ATP1A3 as a target for isolating neuron‐specific extracellular vesicles from human brain and biofluids by Zhengrong Zhang, Yang You, Nadia Sultana, Maria Ericsson, Yuka A Martens, Min Sun, Takahisa Kanekiyo, Seiko Ikezu, Tsuneya Ikezu, Scott A Shaffer (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716642.txt.
Description
Zhengrong Zhang and nine co-authors published a study in 2025 on fishing tiny nerve-cell packages out of blood and spinal fluid. Nerve cells release small vesicles that carry a sample of their contents, which could reveal brain disease without a brain biopsy. The hard part is separating nerve-cell vesicles from all the others in a sample.
The team tested a protein found on nerve cells as a handle for pulling these vesicles out. They compared it with two older handles in samples from lab-grown neurons, brain tissue, fluid, and blood. Microscopy and protein analysis checked how pure each catch was. A clean pull-down method would make blood-based brain tests far more exact.
Catalog record
| CREATOR | Zhengrong Zhang, Yang You, Nadia Sultana, Maria Ericsson, Yuka A Martens, Min Sun, Takahisa Kanekiyo, Seiko Ikezu, Tsuneya Ikezu, Scott A Shaffer |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |