Neuroimaging Markers of Microstructural Neurodegeneration are More Sensitive to Cognitive Dysfunction than Hippocampal Volume in Early Alzheimer’s Disease: A Mixed‐Longitudinal Study
Jason F Moody, Erin M Jonaitis, Rebecca E Langhough, Douglas C Dean, Andrew L Alexander, Sterling C Johnson, Barbara B Bendlin · 2025
Read Neuroimaging Markers of Microstructural Neurodegeneration are More Sensitive to Cognitive Dysfunction than Hippocampal Volume in Early Alzheimer’s Disease: A Mixed‐Longitudinal Study by Jason F Moody, Erin M Jonaitis, Rebecca E Langhough, Douglas C Dean, Andrew L Alexander, Sterling C Johnson, Barbara B Bendlin (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716586.txt.
Description
Jason Moody and co-authors test fine brain scan marks in early Alzheimer's disease in a 2025 study. The classic mark, shrinkage of a memory hub, is broad and late. Finer diffusion marks may catch decay sooner and track thought loss more closely.
Two hundred sixty eight late midlife adults took both scan kinds, some twice. Thought scores came from a three test blend built for early change. Mixed models weigh which marks track scores best. Early diffusion marks, tied in past work to plaque and tangle fluids, shape up as the keener gauges. The study helps stage disease before deep loss sets in.
Catalog record
| CREATOR | Jason F Moody, Erin M Jonaitis, Rebecca E Langhough, Douglas C Dean, Andrew L Alexander, Sterling C Johnson, Barbara B Bendlin |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |