Quantification of PET amyloid [18] Florbetaben using the Centiloid Scale
Maria Rosa Alves da Silva, Cristiano Schaffer Aguzzoli, Fabricio Nery Garrafiel, Ana Maria Marques da Silva, Lucas Porcello Schilling · 2025
Read Quantification of PET amyloid [18] Florbetaben using the Centiloid Scale by Maria Rosa Alves da Silva, Cristiano Schaffer Aguzzoli, Fabricio Nery Garrafiel, Ana Maria Marques da Silva, Lucas Porcello Schilling (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716579.txt.
Description
Maria da Silva and co-authors put a standard ruler on amyloid brain scans in suspected Alzheimer's disease. Amyloid PET readings vary by tracer and lab, so the Centiloid scale rescales them onto one zero-to-one-hundred ladder. The team implemented the scale for Florbetaben scans, reworking a reference data set's pipeline in imaging software.
Twenty-eight anonymized scans were processed with MRI-guided registration and atlas normalization. The resulting spread was wide: eight people fell in the low band, nine in the intermediate band, and eleven in the high band. The authors argue the choice of cutoff genuinely moves diagnosis, and that a common scale makes those choices comparable across clinics. A worked example contrasts a clearly positive and a clearly negative brain.
Catalog record
| CREATOR | Maria Rosa Alves da Silva, Cristiano Schaffer Aguzzoli, Fabricio Nery Garrafiel, Ana Maria Marques da Silva, Lucas Porcello Schilling |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |