Brain Functional Flexibility and its Relationship to the Preclinical Stage of Alzheimer’s Disease
Mohammadali Javanray, Frederic St‐Onge, Pierre Bellec, Bratislav Misic, Jean‐Paul Soucy, Sylvia Villeneuve, PEREVNT‐AD Research Group · 2025
Read Brain Functional Flexibility and its Relationship to the Preclinical Stage of Alzheimer’s Disease by Mohammadali Javanray, Frederic St‐Onge, Pierre Bellec, Bratislav Misic, Jean‐Paul Soucy, Sylvia Villeneuve, PEREVNT‐AD Research Group (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716575.txt.
Description
Mohammadali Javanray and co-authors study brain flexibility in 2025 in people at risk for Alzheimer's disease. The disease's two hallmark proteins build up years before symptoms, yet whether they relate to how flexibly brain networks reconfigure over time was unknown. The team scans 233 healthy adults with a family history of the disease, using both protein imaging and functional brain scans.
They build moment-by-moment maps of how brain regions fluctuate together across 400 nodes, then measure how variable those patterns are, brain-wide and in two early-hit networks. The study compares that flexibility, and standard steady connectivity, against protein levels to probe the silent stage of the disease.
Catalog record
| CREATOR | Mohammadali Javanray, Frederic St‐Onge, Pierre Bellec, Bratislav Misic, Jean‐Paul Soucy, Sylvia Villeneuve, PEREVNT‐AD Research Group |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |