Discordance between CSF and PET biomarkers of amyloid pathology are associated with distinct pathophysiologic process in early stages of Alzheimer’s disease
Binchong An, Danni Li, Lu Men · 2025
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Description
Binchong An, Danni Li, and Lu Men present a 2025 study on why two tests for Alzheimer disease sometimes disagree in early stages. One test reads a protein level in spinal fluid, and the other scans the brain for plaques. Each marks a different step in the disease, so a mismatch may signal distinct biology.
The team sorted 392 people without dementia into four groups by their two test results, all with a normal third marker. They then measured over seven thousand proteins in spinal fluid. Protein gaps between the mismatch groups pointed to different processes at work. The findings could sharpen how early Alzheimer stages are defined and tracked.
Catalog record
| CREATOR | Binchong An, Danni Li, Lu Men |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |