Neurobiological correlates of grey matter morphometry changes in preclinical Alzheimer’s disease
Wiesje Pelkmans, Raffaele Cacciaglia, Gemma Salvadó, Karine Fauria, Carolina Minguillón, Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Jose Luis Molinuevo, Oriol Grau‐Rivera, Rachael E Wilson, Erin M. Jonaitis, Rebecca E. Langhough, Kaj Blennow, Henrik Zetterberg, Sterling C. Johnson, Marc Suárez‐Calvet · 2025
Read Neurobiological correlates of grey matter morphometry changes in preclinical Alzheimer’s disease by Wiesje Pelkmans, Raffaele Cacciaglia, Gemma Salvadó, Karine Fauria, Carolina Minguillón, Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Jose Luis Molinuevo, Oriol Grau‐Rivera, Rachael E Wilson, Erin M. Jonaitis, Rebecca E. Langhough, Kaj Blennow, Henrik Zetterberg, Sterling C. Johnson, Marc Suárez‐Calvet (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716567.txt.
Description
Wiesje Pelkmans and co-authors linked fluid biomarker patterns to brain volume changes in people with no symptoms but early Alzheimer changes, in work published in 2025. The catalog byline ends one name earlier than the head byline, so team framing is used. More than six hundred adults had spinal fluid tests and repeat brain scans over about three and a half years.
Six marker patterns were extracted from the fluid panel. A pattern of pure amyloid change tied to wide volume loss and faster decline. A star cell pattern tied to volume gains in some regions yet faster decline when amyloid was present. A mixed tau and injury pattern tied to shrinkage in front and side regions. The authors say several cell processes drive early brain change at once.
Catalog record
| CREATOR | Wiesje Pelkmans, Raffaele Cacciaglia, Gemma Salvadó, Karine Fauria, Carolina Minguillón, Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Jose Luis Molinuevo, Oriol Grau‐Rivera, Rachael E Wilson, Erin M. Jonaitis, Rebecca E. Langhough, Kaj Blennow, Henrik Zetterberg, Sterling C. Johnson, Marc Suárez‐Calvet |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |