Substantia nigra iron deposition in Lewy body disease: an MRI quantitative susceptibility mapping and neuropathology study
Patricia Diaz‐Galvan, Scott A. Przybelski, Timothy G. Lesnick, Aivi T. Nguyen, Melissa E. Murray, Ross R. Reichard, Dennis W. Dickson, Daisuke Ono, Christopher G. Schwarz, Matthew L. Senjem, Jeffrey L. Gunter, Val J. Lowe, Leah K. Forsberg, Julie A. Fields, Rodolfo Savica, Jonathan Graff‐Radford, Vi · 2025
Read Substantia nigra iron deposition in Lewy body disease: an MRI quantitative susceptibility mapping and neuropathology study by Patricia Diaz‐Galvan, Scott A. Przybelski, Timothy G. Lesnick, Aivi T. Nguyen, Melissa E. Murray, Ross R. Reichard, Dennis W. Dickson, Daisuke Ono, Christopher G. Schwarz, Matthew L. Senjem, Jeffrey L. Gunter, Val J. Lowe, Leah K. Forsberg, Julie A. Fields, Rodolfo Savica, Jonathan Graff‐Radford, Vi (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716564.txt.
Description
Patricia Diaz-Galvan and a large team checked whether iron buildup seen on brain scans truly reflects Lewy body disease, the process behind Parkinson disease and one major dementia. A scan method called quantitative susceptibility mapping can measure iron in the substantia nigra, the small region that degenerates in these illnesses. But scan findings are rarely checked against the brain itself. Every one of their 54 cases had both a scan in life and an autopsy after death.
Thirteen cases proved to carry Lewy pathology and forty-two did not. The team compared iron readings for the whole substantia nigra and its two subregions between the groups. Alzheimer changes coexisted in most of the Lewy-positive cases. The study supplies the missing validation step for an imaging marker that clinics increasingly use.
Catalog record
| CREATOR | Patricia Diaz‐Galvan, Scott A. Przybelski, Timothy G. Lesnick, Aivi T. Nguyen, Melissa E. Murray, Ross R. Reichard, Dennis W. Dickson, Daisuke Ono, Christopher G. Schwarz, Matthew L. Senjem, Jeffrey L. Gunter, Val J. Lowe, Leah K. Forsberg, Julie A. Fields, Rodolfo Savica, Jonathan Graff‐Radford, Vi |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |