Identification of CSF proteins in Alzheimer’s Disease highly correlated with [18F]GTP1
Julie Lee · 2025
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Description
Lee searches spinal fluid for proteins that track a tau imaging signal in Alzheimer's disease, in this 2025 conference abstract. Tau tangles drive the disease, and brain scans can map them, but scans are costly and need special centers. A fluid test that mirrors the scan would widen access in trials.
Samples came from two trials of an experimental tau drug. A mass spectrometry method measured over three thousand proteins in each sample. Participants also received the tau scan, scored across five brain regions. Lee's analysis hunted for proteins whose levels rose and fell with the scan values. Such proteins could serve as cheaper stand-ins for imaging. The work supports fluid markers of tau burden.
Catalog record
| CREATOR | Julie Lee |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |