Blood biomarker profiles in autopsy‐diagnosed carriers of different PSEN1 mutations relative to sporadic Alzheimer’s disease and controls
Tara K Lafferty, Anuradha Sehrawat, Xuemei Zeng, Yijun Chen, William E Klunk, Tharick A Pascoal, Ann D Cohen, Victor L Villemagne, M Ilyas Kamboh, Oscar L Lopez, Eric E Abrahamson, Sarah Berman, Julia Kofler, Milos D Ikonomovic, Thomas K Karikari · 2025
Read Blood biomarker profiles in autopsy‐diagnosed carriers of different PSEN1 mutations relative to sporadic Alzheimer’s disease and controls by Tara K Lafferty, Anuradha Sehrawat, Xuemei Zeng, Yijun Chen, William E Klunk, Tharick A Pascoal, Ann D Cohen, Victor L Villemagne, M Ilyas Kamboh, Oscar L Lopez, Eric E Abrahamson, Sarah Berman, Julia Kofler, Milos D Ikonomovic, Thomas K Karikari (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716547.txt.
Description
Tara Lafferty and colleagues read blood biomarkers in people whose Alzheimer's disease came from inherited PSEN1 mutations, confirmed at autopsy. Six mutation carriers, sporadic cases and healthy controls had plasma tested for tau, damage and amyloid markers during life. Two mutations in the set were known to cause disease, three were of unclear standing, and one case was not yet typed.
Two tau markers ran five to eightfold high in mutation carriers against controls, and a glial marker ran fourfold high in both disease groups. A nerve damage marker peaked in sporadic cases instead. Amyloid blood measures did not separate the groups. The known mutations carried the highest readings overall.
Catalog record
| CREATOR | Tara K Lafferty, Anuradha Sehrawat, Xuemei Zeng, Yijun Chen, William E Klunk, Tharick A Pascoal, Ann D Cohen, Victor L Villemagne, M Ilyas Kamboh, Oscar L Lopez, Eric E Abrahamson, Sarah Berman, Julia Kofler, Milos D Ikonomovic, Thomas K Karikari |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |