Tau accumulation mediates β‐amyloid effects on hippocampal atrophy and memory in early Alzheimer’s disease
Sofia Fernandez‐Lozano, Vladimir S Fonov, Joseph Therriault, Nesrine Rahmouni, Stijn Servaes, Jenna Stevenson, Nina Marguerita Poltronetti, Pedro Rosa‐Neto, D Louis Collins · 2025
Read Tau accumulation mediates β‐amyloid effects on hippocampal atrophy and memory in early Alzheimer’s disease by Sofia Fernandez‐Lozano, Vladimir S Fonov, Joseph Therriault, Nesrine Rahmouni, Stijn Servaes, Jenna Stevenson, Nina Marguerita Poltronetti, Pedro Rosa‐Neto, D Louis Collins (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716536.txt.
Description
Sofia Fernandez-Lozano and eight co-authors published a study in 2025 on the chain linking amyloid, tau, shrinkage, and memory loss in early Alzheimer's disease. All four move together, but the order of cause and effect is hard to prove. The team modeled the chain directly in people who were still healthy or mildly impaired.
They used a Canadian cohort with memory tests, MRI scans, and two kinds of PET scan across 333 visits. A region-selection method picked the brain areas where amyloid and tau mattered most for memory. The models then tested whether tau and hippocampal shrinkage carry amyloid's effect into memory loss. Tracing this chain shows where a drug might break it.
Catalog record
| CREATOR | Sofia Fernandez‐Lozano, Vladimir S Fonov, Joseph Therriault, Nesrine Rahmouni, Stijn Servaes, Jenna Stevenson, Nina Marguerita Poltronetti, Pedro Rosa‐Neto, D Louis Collins |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |