Hispanic/Latino ethnicity moderates the plasma P‐tau217 and memory relationship in older adults across the cognitive continuum
Shannon Y Lee, Olivia M Emanuel, Emily F Matusz, Jessica Bove, Jacob Fiala, Franchesca Arias, Shellie‐Anne Levy, Michael Marsiske, Monica Rosselli, Rosie E Curiel, David A Loewenstein, Ranjan Duara, Idaly Velez‐Uribe, Warren W Barker, David Vaillancourt, Melissa J Armstrong, Glenn E Smith, Breton M · 2025
Read Hispanic/Latino ethnicity moderates the plasma P‐tau217 and memory relationship in older adults across the cognitive continuum by Shannon Y Lee, Olivia M Emanuel, Emily F Matusz, Jessica Bove, Jacob Fiala, Franchesca Arias, Shellie‐Anne Levy, Michael Marsiske, Monica Rosselli, Rosie E Curiel, David A Loewenstein, Ranjan Duara, Idaly Velez‐Uribe, Warren W Barker, David Vaillancourt, Melissa J Armstrong, Glenn E Smith, Breton M (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716535.txt.
Description
Lee and co-authors test a blood marker's meaning across ethnic groups in a 2025 study. A plasma protein fragment, P-tau217, flags Alzheimer type brain change with high accuracy. Most validation cohorts, though, were ethnically narrow. The team asked whether the marker's link to memory scores depends on ethnicity, comparing Hispanic and Latino elders with non Hispanic White peers across the cognitive range.
If the link shifts by group, cutoffs tuned on one population could misread another. Subjective decline and mild impairment cases joined healthy elders in the sample. Blood tests promise cheap, wide screening for dementia risk; fairness across groups decides whether that promise holds for everyone.
Catalog record
| CREATOR | Shannon Y Lee, Olivia M Emanuel, Emily F Matusz, Jessica Bove, Jacob Fiala, Franchesca Arias, Shellie‐Anne Levy, Michael Marsiske, Monica Rosselli, Rosie E Curiel, David A Loewenstein, Ranjan Duara, Idaly Velez‐Uribe, Warren W Barker, David Vaillancourt, Melissa J Armstrong, Glenn E Smith, Breton M |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |