The relationship between APOE genotype and dementia varies by genetic ancestry and race/ethnicity
Marian J Gilmore, Alexandra M Varga, Catherine Schaefer, Yambazi Banda, Thomas J. Hoffmann, M. Maria Glymour, Sheila A Weinmann, Hélène Choquet, Ning Smith, Paola Gilsanz, Stefan Massimino, Willa D Brenowitz · 2025
Read The relationship between APOE genotype and dementia varies by genetic ancestry and race/ethnicity by Marian J Gilmore, Alexandra M Varga, Catherine Schaefer, Yambazi Banda, Thomas J. Hoffmann, M. Maria Glymour, Sheila A Weinmann, Hélène Choquet, Ning Smith, Paola Gilsanz, Stefan Massimino, Willa D Brenowitz (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716532.txt.
Description
Marian Gilmore and co-authors test how a gene risk for dementia varies by ancestry in 2025. The APOE gene shapes dementia risk, but its force may differ across groups. Most past work rests on European ancestry samples. The team drew on a large California health system biobank with rich records.
Members gave gene data and surveys, linked to their medical records over many years. Ancestry shares were estimated from the gene data itself. Models then weighed gene risk within ancestry and ethnic groups. The findings caution against applying one risk figure to all patients in clinic counseling.
Catalog record
| CREATOR | Marian J Gilmore, Alexandra M Varga, Catherine Schaefer, Yambazi Banda, Thomas J. Hoffmann, M. Maria Glymour, Sheila A Weinmann, Hélène Choquet, Ning Smith, Paola Gilsanz, Stefan Massimino, Willa D Brenowitz |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |