Plasma and neuroimaging biomarkers of small vessel disease and Alzheimer’s disease in a diverse cohort
Samuel N Lockhart, Courtney L Sutphen, Jordan E Tanley, Fernando Gonzalez‐Ortiz, Przemyslaw Radoslaw Kac, Mohamad Habes, Susan R Heckbert, Nicholas J Ashton, Michelle M Mielke, Christopher T Whitlow, Kevin Hiatt, Suzanne Craft, Thomas C Register, Kathleen M Hayden, Stephen R Rapp, Henrik Zetterberg, · 2025
Read Plasma and neuroimaging biomarkers of small vessel disease and Alzheimer’s disease in a diverse cohort by Samuel N Lockhart, Courtney L Sutphen, Jordan E Tanley, Fernando Gonzalez‐Ortiz, Przemyslaw Radoslaw Kac, Mohamad Habes, Susan R Heckbert, Nicholas J Ashton, Michelle M Mielke, Christopher T Whitlow, Kevin Hiatt, Suzanne Craft, Thomas C Register, Kathleen M Hayden, Stephen R Rapp, Henrik Zetterberg, (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716530.txt.
Description
Samuel Lockhart and a large team studied blood and brain imaging markers in a diverse older cohort. Their 2025 paper links plasma markers of Alzheimer's disease with small vessel disease in the brain. Little was known about how these two marker sets relate in late life. Data came from 251 participants in a long-running multi-ethnic study.
Most participants had normal cognition, while some had mild impairment or probable dementia. Cognitive status tracked with both imaging and plasma markers. Lower levels of one amyloid ratio linked to smaller brain volumes. Higher levels of other markers linked to white matter damage and microbleeds. Tau markers in blood also tracked with amyloid deposits on brain scans. The findings tie blood tests to both vessel and Alzheimer's changes.
Catalog record
| CREATOR | Samuel N Lockhart, Courtney L Sutphen, Jordan E Tanley, Fernando Gonzalez‐Ortiz, Przemyslaw Radoslaw Kac, Mohamad Habes, Susan R Heckbert, Nicholas J Ashton, Michelle M Mielke, Christopher T Whitlow, Kevin Hiatt, Suzanne Craft, Thomas C Register, Kathleen M Hayden, Stephen R Rapp, Henrik Zetterberg, |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |