A DAT1 gene and APOE ε4 interaction is associated with apathy and structural brain changes in Alzheimer’s Disease
Rubina Malik, Derek Beaton, Andrew J. Saykin, Kwangsik Nho, Elizabeth Finger · 2025
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Description
Rubina Malik and co-workers link a dopamine gene interaction to apathy and brain shrinkage in Alzheimer's disease, in a 2025 paper. Apathy is a heavy burden in the disease but its biology is poorly mapped. The team used a large imaging initiative dataset of more than a thousand participants.
A multivariate method modeled gene variants, whole-brain structure, and apathy together. Apathy clustered with one combined genotype: carrying the known APOE risk variant plus two minor copies of a dopamine transporter gene. That pattern also tracked with brain atrophy. The authors say the dopamine link may guide future apathy trials and point to new treatment targets.
Catalog record
| CREATOR | Rubina Malik, Derek Beaton, Andrew J. Saykin, Kwangsik Nho, Elizabeth Finger |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 1 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |