The Role of ApoE4 in The Acceleration of Tau Aggregation
Anna Steward, Davina Biel, Sebastian Niclas Roemer, Zeyu Zhu, Julia Pescoller, Fabian Wagner, Mattes Gross, Martin Dichgans, Michael Ewers, Amir Dehsarvi, Matthias Brendel, Nicolai Franzmeier · 2025
Read The Role of ApoE4 in The Acceleration of Tau Aggregation by Anna Steward, Davina Biel, Sebastian Niclas Roemer, Zeyu Zhu, Julia Pescoller, Fabian Wagner, Mattes Gross, Martin Dichgans, Michael Ewers, Amir Dehsarvi, Matthias Brendel, Nicolai Franzmeier (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716522.txt.
Description
Anna Steward and co-authors ask where a key Alzheimer's risk gene speeds up tau damage in the brain, in a 2025 study. The gene variant, ApoE4, is tied to earlier tau buildup at lower levels of the amyloid protein. Whether it acts at the first release of tau into spinal fluid or at the later clumping stage was unclear.
The team study 287 people without dementia, using spinal fluid measures and brain scans for both proteins. ApoE4 did not change how amyloid levels tracked early tau release. It did strengthen the link between that early tau signal and later tau clumping on scans, above all in people still thinking normally. The effect was strongest in brain regions that express the gene most. ApoE4 thus seems to act at the clumping step, early in the disease.
Catalog record
| CREATOR | Anna Steward, Davina Biel, Sebastian Niclas Roemer, Zeyu Zhu, Julia Pescoller, Fabian Wagner, Mattes Gross, Martin Dichgans, Michael Ewers, Amir Dehsarvi, Matthias Brendel, Nicolai Franzmeier |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |