Complement proteins C1q, C3, and Factor H are associated with early tau pathology and synaptic integrity in persons with pre‐symptomatic Alzheimer’s disease
Julia Loncke, Cynthia Picard, Anne Labonté, Henrik Zetterberg, Kaj Blennow, Ann Brinkmalm, John C.S. Breitner, Judes Poirier, The PREVENT‐AD Research Group · 2025
Read Complement proteins C1q, C3, and Factor H are associated with early tau pathology and synaptic integrity in persons with pre‐symptomatic Alzheimer’s disease by Julia Loncke, Cynthia Picard, Anne Labonté, Henrik Zetterberg, Kaj Blennow, Ann Brinkmalm, John C.S. Breitner, Judes Poirier, The PREVENT‐AD Research Group (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716422.txt.
Description
Loncke and co-authors report in 2025 on immune proteins in spinal fluid and early brain change before any signs of illness show. They studied 160 adults at high risk due to family history, with 566 fluid samples taken over five years. The proteins they tracked help the brain clear spare links between nerve cells.
When that clearing runs too far, the brain can lose links it needs and shrink. The team set protein levels next to fluid signs of the plaques and tangles of the disease, and next to signs of worn nerve links. Early shifts in these proteins may help spot the disease in its silent phase and point to new ways to slow it.
Catalog record
| CREATOR | Julia Loncke, Cynthia Picard, Anne Labonté, Henrik Zetterberg, Kaj Blennow, Ann Brinkmalm, John C.S. Breitner, Judes Poirier, The PREVENT‐AD Research Group |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |