Allostatic Load and its Impact on amyloid, tau, and hippocampus: a potential underlying mechanism explaining variability in Alzheimer's Disease pathology and progression
Juliana Nery Souza‐Talarico, Maria Hein, Yelena Perkhounkova, Jihye Lee · 2025
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Description
Juliana Nery Souza-Talarico and co-authors look in 2025 at why some people with brain changes linked to Alzheimer's disease get worse while others stay sharp. Two proteins build up in the brain years before symptoms start, yet not all people with that build up go on to lose memory. The team asks if long term stress on the body helps explain that gap.
They focus on the wear that long term stress leaves on the body, and how it may link to the two proteins and to shrinkage of a brain area tied to memory. If stress wear speeds up harm, then it could help flag who is at most risk. It could also point to steps that slow the disease down. The paper sets out this idea as a path worth testing in care and in research.
Catalog record
| CREATOR | Juliana Nery Souza‐Talarico, Maria Hein, Yelena Perkhounkova, Jihye Lee |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |