AssociatIion of metabotropic glutamate receptor 5 with amyloid deposition in Alzheimer's disease's patient and mouse models
Serena Savoldelli, Yanyan Kong, Cinzia Maschio, Uwe Konetiko, Linjing Mu, Jan Klohs, Roger M. Nitsch, Ruiqing Ni · 2025
Read AssociatIion of metabotropic glutamate receptor 5 with amyloid deposition in Alzheimer's disease's patient and mouse models by Serena Savoldelli, Yanyan Kong, Cinzia Maschio, Uwe Konetiko, Linjing Mu, Jan Klohs, Roger M. Nitsch, Ruiqing Ni (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716392.txt.
Description
Serena Savoldelli and seven co-authors measured a brain receptor in Alzheimer's disease, in a 2025 study. The receptor helps pass signals between nerve cells and plays a part in learning and memory. The team asked how its levels in the hippocampus change with the disease, and how they relate to amyloid buildup.
In brain tissue from patients, receptor levels were lower than in controls who had no dementia. In one mouse model, a tracer for the receptor also read low, and low levels sat near amyloid clumps. A second mouse model gave a mixed picture, with some linked genes raised. The authors conclude that change in this receptor depends in part on the model used.
Catalog record
| CREATOR | Serena Savoldelli, Yanyan Kong, Cinzia Maschio, Uwe Konetiko, Linjing Mu, Jan Klohs, Roger M. Nitsch, Ruiqing Ni |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |