Synaptic loss pattern is associated with functional connectivity in Alzheimer’s disease
Ying Luan, Weiyi Wang, Qi Huang, Yihui Guan, Binyin Li, Michael Schöll, Nicolai Franzmeier, Fang Xie · 2025
Read Synaptic loss pattern is associated with functional connectivity in Alzheimer’s disease by Ying Luan, Weiyi Wang, Qi Huang, Yihui Guan, Binyin Li, Michael Schöll, Nicolai Franzmeier, Fang Xie (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716387.txt.
Description
Ying Luan and co-authors report a 2025 study on how loss of synapses spreads through the brain in Alzheimer's disease. Synapses are the links that let brain cells pass signals, and their loss tracks closely with loss of memory. A harmful protein can hurt these links and may move from cell to cell along wired paths.
The study scanned 76 people with disease plaques and 48 healthy peers with no plaques. It then mapped how loss in one area lined up with loss in areas wired to it. Areas that were close in the wiring map to the worst hit spots had lost more synapses. The pattern hints that loss spreads along the brain's own links.
Catalog record
| CREATOR | Ying Luan, Weiyi Wang, Qi Huang, Yihui Guan, Binyin Li, Michael Schöll, Nicolai Franzmeier, Fang Xie |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |