Cerebrospinal fluid concentration of furin in patients with Alzheimer’s disease
Agnieszka Kulczynska‐Przybik, Jan Mroczko, Maciej Dulewicz, Henrik Zetterberg, Jörg Hanrieder, Kaj Blennow, Daria Krawczuk, Julia Doroszkiewicz, Renata Borawska, Agnieszka Slowik, Barbara Mroczko · 2025
Read Cerebrospinal fluid concentration of furin in patients with Alzheimer’s disease by Agnieszka Kulczynska‐Przybik, Jan Mroczko, Maciej Dulewicz, Henrik Zetterberg, Jörg Hanrieder, Kaj Blennow, Daria Krawczuk, Julia Doroszkiewicz, Renata Borawska, Agnieszka Slowik, Barbara Mroczko (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716381.txt.
Description
Agnieszka Kulczynska-Przybik and co-authors measure a protein-cutting enzyme in Alzheimer's patients in this 2025 study. The enzyme, furin, trims many precursor proteins into their active forms. Those targets include proteins tied to neuron survival, growth, and inflammation.
Steady furin activity helps keep the brain in balance, and its failure may feed degeneration. The team measured furin levels in spinal fluid from patients with Alzheimer's disease. The question is whether those levels mark the disease or its stage. A fluid marker tied to a core processing enzyme could aid diagnosis. It might also point to a pathway worth treating.
Catalog record
| CREATOR | Agnieszka Kulczynska‐Przybik, Jan Mroczko, Maciej Dulewicz, Henrik Zetterberg, Jörg Hanrieder, Kaj Blennow, Daria Krawczuk, Julia Doroszkiewicz, Renata Borawska, Agnieszka Slowik, Barbara Mroczko |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |