Similarity of regional brain blood flow and glucose utilization imaging biomarkers in older adults
Rebecca J Lepping, Jasmine M Taylor, Robyn A Honea, Benjamin J Hess, Eric D Vidoni, William M Brooks, Jeffrey M Burns, Russell H Swerdlow · 2025
Read Similarity of regional brain blood flow and glucose utilization imaging biomarkers in older adults by Rebecca J Lepping, Jasmine M Taylor, Robyn A Honea, Benjamin J Hess, Eric D Vidoni, William M Brooks, Jeffrey M Burns, Russell H Swerdlow (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716377.txt.
Description
Rebecca Lepping and co-authors compare two brain imaging markers in older adults in a 2025 study. Blood flow and glucose use both flag Alzheimer's changes. Flow delivers the glucose cells burn, yet they are distinct signals. Whether the scans tell the same story was the question.
One hundred eight older adults spanned healthy to demented status. Each completed structural and flow imaging plus a glucose scan. Large cortical regions were defined per person. Flow values and glucose uptake were extracted region by region. The two markers correlated positively and significantly in key areas. Cingulate regions led the reported associations. Disease groups ranged from unimpaired to Alzheimer's dementia. Shared variance suggests overlapping information content. Distinct physiology might still add separate value elsewhere. The authors map where the markers agree regionally. Scan selection for studies can use this overlap. Cheaper flow imaging might substitute in some contexts.
Catalog record
| CREATOR | Rebecca J Lepping, Jasmine M Taylor, Robyn A Honea, Benjamin J Hess, Eric D Vidoni, William M Brooks, Jeffrey M Burns, Russell H Swerdlow |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |