Quantitative dissection of healthy aging using protein and peptide signatures from paired CSF and plasma
Polina Shichkova, Aida Kamalian, Marco Tognetti, Christopher Below, Roland Bruderer, Yuehan Feng, Michael W Lutz, Abhay Moghekar · 2025
Read Quantitative dissection of healthy aging using protein and peptide signatures from paired CSF and plasma by Polina Shichkova, Aida Kamalian, Marco Tognetti, Christopher Below, Roland Bruderer, Yuehan Feng, Michael W Lutz, Abhay Moghekar (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716267.txt.
Description
Polina Shichkova and co-authors published this study in two thousand twenty-five on how aging changes proteins in blood and spinal fluid. Age is the top risk factor for Alzheimer's disease, yet healthy aging and disease aging are hard to tell apart.
The team took paired blood and spinal fluid samples from ninety-three people at Johns Hopkins clinics, both young adults and healthy older adults. A mass spectrometry method counted tens of thousands of protein pieces in each fluid. The reads covered paths tied to amyloid, tau, nerve harm, swelling, and iron damage. The team paid close heed to protein pieces cut or joined in ways that mark disease steps. Their map gives a base line of normal aging that later disease studies can measure against.
Catalog record
| CREATOR | Polina Shichkova, Aida Kamalian, Marco Tognetti, Christopher Below, Roland Bruderer, Yuehan Feng, Michael W Lutz, Abhay Moghekar |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |