Accelerated Temporal Cortex Tau Accumulation Mediates the Effects of Low Physical Activity on Faster Cognitive Decline in Preclinical Alzheimer’s Disease
Wai‐Ying Wendy Yau, Dylan Kirn, Jennifer S Rabin, Michael J Properzi, Aaron P Schultz, Dorene M. Rentz, Keith A Johnson, Reisa A Sperling, Jasmeer P. Chhatwal · 2025
Read Accelerated Temporal Cortex Tau Accumulation Mediates the Effects of Low Physical Activity on Faster Cognitive Decline in Preclinical Alzheimer’s Disease by Wai‐Ying Wendy Yau, Dylan Kirn, Jennifer S Rabin, Michael J Properzi, Aaron P Schultz, Dorene M. Rentz, Keith A Johnson, Reisa A Sperling, Jasmeer P. Chhatwal (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716240.txt.
Description
Wai-Ying Wendy Yau and co-authors report a 2025 study on low daily activity, brain change, and loss of thinking skill. The work looks at people who have brain plaques tied to Alzheimer's disease but no symptoms yet. Past work from the same long study linked low activity to faster loss of skill in this group.
The team tracked 293 older adults with no symptoms at the start, some for up to 13 years. A belt step counter worn for one week gave a base rate of steps per day. Low activity paired with high plaque load linked to faster loss of skill. The link ran through faster growth of tau, a second harmful protein, in parts of the side brain.
Catalog record
| CREATOR | Wai‐Ying Wendy Yau, Dylan Kirn, Jennifer S Rabin, Michael J Properzi, Aaron P Schultz, Dorene M. Rentz, Keith A Johnson, Reisa A Sperling, Jasmeer P. Chhatwal |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |