Exploring the utility of Plasma GFAP as a secondary endpoint in Alzheimer's disease Clinical trials to monitor disease progression
Sarah Abbas, Pamela C.L. Ferreira, Bruna Bellaver, Guilherme Povala, Francieli Rohden, Cristiano Schaffer Aguzzoli, Hussein Zalzale, Guilherme Bauer‐Negrini, Carolina Soares, João Pedro Ferrari‐Souza, Douglas Teixeira Leffa, Firoza Z Lussier, Marina Scop Madeiros, Matheus Scarpatto Rodrigues, Markle · 2025
Read Exploring the utility of Plasma GFAP as a secondary endpoint in Alzheimer's disease Clinical trials to monitor disease progression by Sarah Abbas, Pamela C.L. Ferreira, Bruna Bellaver, Guilherme Povala, Francieli Rohden, Cristiano Schaffer Aguzzoli, Hussein Zalzale, Guilherme Bauer‐Negrini, Carolina Soares, João Pedro Ferrari‐Souza, Douglas Teixeira Leffa, Firoza Z Lussier, Marina Scop Madeiros, Matheus Scarpatto Rodrigues, Markle (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716235.txt.
Description
Sarah Abbas and co-authors test a blood marker as a trial gauge for Alzheimer's disease in a 2025 paper. The marker, a protein from brain support cells, has been tied to harmful brain deposits and to thought loss, and drug trials already track its fall as a side signal.
Ninety four impaired adults with confirmed deposits came from two cohorts. Blood marker levels at start and follow up were compared, and hazard models asked whether change in the marker foresaw later decline. The study judges whether the marker earns a formal place as a secondary trial endpoint.
Catalog record
| CREATOR | Sarah Abbas, Pamela C.L. Ferreira, Bruna Bellaver, Guilherme Povala, Francieli Rohden, Cristiano Schaffer Aguzzoli, Hussein Zalzale, Guilherme Bauer‐Negrini, Carolina Soares, João Pedro Ferrari‐Souza, Douglas Teixeira Leffa, Firoza Z Lussier, Marina Scop Madeiros, Matheus Scarpatto Rodrigues, Markle |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |