Seeding and propagation of Tau from the retina to the brain in TAU58 mice
Grzegorz Walkiewicz, Alicja Ronisz, Simona Ospitalieri, Sandra O Tomé, Rik Vandenberghe, Lies De Groef, Dietmar Rudolf Thal · 2025
Read Seeding and propagation of Tau from the retina to the brain in TAU58 mice by Grzegorz Walkiewicz, Alicja Ronisz, Simona Ospitalieri, Sandra O Tomé, Rik Vandenberghe, Lies De Groef, Dietmar Rudolf Thal (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716223.txt.
Description
Grzegorz Walkiewicz and co-authors test whether harmful tau protein can spread from the eye into the brain, in a 2025 mouse study. The retina is part of the central nervous system and can gather the same proteins seen in Alzheimer's disease. A distinct form of tau buildup in the retina might act as an early warning sign. What stayed unclear was whether that buildup could seed damage deeper in the brain.
The team used mice bred to make a mutant human tau protein. Extracts from human brains with tau disease were injected under the retina of young mice. Retinal tau grew with age in the mice and came with loss of nerve cells. Extracts from Alzheimer's brains sped up retinal changes and seeded tau in a visual relay area of the brain, showing spread from eye to brain.
Catalog record
| CREATOR | Grzegorz Walkiewicz, Alicja Ronisz, Simona Ospitalieri, Sandra O Tomé, Rik Vandenberghe, Lies De Groef, Dietmar Rudolf Thal |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |