Brainstem Atrophy across the AD Clinical Spectrum: An Automated Volumetric MRI study
Deepali M Bhalla, Barbara B. Bendlin, Piero G. Antuono, Elias Granadillo · 2025
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Description
Deepali Bhalla and co-authors measure brainstem shrinkage across the Alzheimer spectrum in a 2025 paper. The brainstem, and one small cluster inside it, may be among the first places Alzheimer disease strikes, which could explain early sleep and mood changes. Proving that needs special scans rare outside research labs. The team instead used standard MRI plus automated volume software on three hundred clinic patients.
Patients fell into three groups: vague complaints, mild impairment, and dementia. Brainstem volume did not differ across them, while the hippocampus, a memory structure, shrank as expected toward dementia. Men showed smaller brainstems than women at every stage. The authors allow that the software may miss tiny sub-regions, or that the study lacked power, and call for finer tools.
Catalog record
| CREATOR | Deepali M Bhalla, Barbara B. Bendlin, Piero G. Antuono, Elias Granadillo |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |