Synthetic γ‐AApeptides as Targeting Ligands for Immunomagnetic separation of Alzheimer’s disease (AD) Biomarkers
Yuancheng Li, Hui Mao, Jianfeng Cai, Hedi Ma, Jonathan Padelford · 2025
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Description
Yuancheng Li and co-authors build a lab-made molecule that can fish a key Alzheimer's marker out of blood or spinal fluid, in a 2025 paper. Tests for the disease often rely on antibodies to grab amyloid beta, a protein fragment tied to the illness. Antibodies vary between batches and spoil in storage. The team offers a synthetic stand-in built from a chain of modified amino acid units.
The researchers made a large library of these synthetic chains and screened it for ones that grip a form of amyloid called Aβ40. They mapped the winning chains with lab instruments, then fixed them to magnetic beads. The beads can pull the target protein out of a sample for measurement. A stable, factory-made gripper like this could make fluid tests for the disease cheaper and more steady.
Catalog record
| CREATOR | Yuancheng Li, Hui Mao, Jianfeng Cai, Hedi Ma, Jonathan Padelford |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |