Greater locus coeruleus integrity predicts less accumulation of plasma pTau231 and GFAP over time
McKenna E. Williams, Christine Fennema‐Notestine, Tyler R. Bell, Carol E. Franz, Stephen J. Glatt, Matthew S. Panizzon, Robert A. Rissman, William S. Kremen, Jeremy A. Elman · 2025
Read Greater locus coeruleus integrity predicts less accumulation of plasma pTau231 and GFAP over time by McKenna E. Williams, Christine Fennema‐Notestine, Tyler R. Bell, Carol E. Franz, Stephen J. Glatt, Matthew S. Panizzon, Robert A. Rissman, William S. Kremen, Jeremy A. Elman (2025) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11716176.txt.
Description
McKenna Williams and co-authors link a tiny brain hub to later blood signs of Alzheimer disease in a 2025 study. The hub, the locus coeruleus, is among the first places a harmful protein builds. Its health may both mark early change and shape what follows.
The group held 669 men from a twin aging study, all clear of memory loss at the start. Brain scans rated the hub, and blood was tracked over about five and a half years. Men with a stronger hub signal gained less of two blood markers over time, the title reports. Age alone raised both markers. If the hub can be read early, it may help spot who is on a faster path years before symptoms show.
Catalog record
| CREATOR | McKenna E. Williams, Christine Fennema‐Notestine, Tyler R. Bell, Carol E. Franz, Stephen J. Glatt, Matthew S. Panizzon, Robert A. Rissman, William S. Kremen, Jeremy A. Elman |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |