Polygenic risk for schizophrenia predicts dopamine‐related grey matter volume alterations in people with Alzheimer’s disease and psychotic symptoms
Riccardo Manca, Annalena Venneri · 2025
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Description
Riccardo Manca and Annalena Venneri asked in 2025 whether inherited risk for schizophrenia reshapes the brains of people who develop psychosis alongside Alzheimer disease. Psychotic symptoms appear in Alzheimer disease more often in later stages and in patients whose genomes carry more schizophrenia-linked variants. Those symptoms also come with changes in grey matter volume.
Eight hundred participants from a national Alzheimer data base had genetic scores computed, split between 203 cognitively unimpaired people and 597 with Alzheimer disease. The Alzheimer group divided into 121 with psychosis and 476 without, by a standard symptom questionnaire. The team tested whether the risk score explains how grey matter tracks the brain maps of dopamine and serotonin systems. Readers get a genetic bridge between two disorders that meet in the clinic.
Catalog record
| CREATOR | Riccardo Manca, Annalena Venneri |
|---|---|
| YEAR | 2025 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |